Allergy 1-5

Interleukin-10 promoter polymorphisms and asthma risk: A meta-analysis

W. Nie, Z. Fang, B. Li and Q. Y. Xiu

Cytokine.2012 Dec;60(3):849-855.

Abstract: Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two authors. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Seventeen potentially eligible articles were identified (4478 cases and 4803 controls). Significant associations between -1082A/G and -592A/C polymorphisms and asthma were observed. However, there was no significant association between -819T/C polymorphism and asthma risk. In addition, there were significant associations of the IL-10 haplotypes with asthma. In summary, this meta-analysis suggested that IL-10 promoter polymorphisms were associated with asthma risk. (C) 2012 Published by Elsevier Ltd.

*Times cited: 5

Keywords: Asthma, Interleukin-10, Meta-analysis, Polymorphism, gene polymorphisms, bronchial-asthma, cytokine production, mast-cells, il-10, association, children, inflammation, generation, phenotypes

Link: http://www.ncbi.nlm.nih.gov/pubmed/23017230

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