Iran J Allergy Asthma Immunol 2013 Aug 28; 12(4):397-9

Hallucination Development with Montelukast in a Child with Asthma: Case Presentation.

Kocyigit A1, Gulcan Oksuz B1, Yarar F2, Uzun F3, Igde M1, Islek I4

 

1 Samsun Education and Research Hospital, Samsun, Turkey

2 Samsun Ondokuz Mayis University, Samsun, Turkey

3 Samsun Maternity and Children Hospital, Samsun, Turkey

4 Istanbul Umraniye Education and Research Hospital, Istanbul, Turkey

 

Corresponding Author:

Banu Gulcan Oksuz, MD

Samsun Education and Research Hospital, Samsun, Turkey

E-mail: banugulcan@gmail.com

 

Abstract

Leukotriene receptor antagonists (montelukast) have been used for many years in the treatment of asthma both acute and chronic stages. They are accepted commonly as safe but mostly possible side effects are ignored. However, montelukast also could lead to important adverse reactions like hallucinations. In literature only 2 reports have been found about hallucinations with it. One is a study which reports 3 patients from 48 children and the other is a 29 year-old case report. In our case, psychiatric adverse reactions of montelukast, especially hallucinations are reported similarly. We are presenting a child who had visual hallucinations after starting to use montelukast and after stopping the medicine these complaints disappeared in 48 hours. Although it is a safe drug, it should not be forgotten that it has psychiatric side effects which may be missed easily especially in children.

Keywords: Adverse reactions; Asthma; Hallucination; Children; Montelukast

PMID: 23996717

 

Supplements:

Leukotrien receptor antagonists are important drugs that take place in the treatment of pediatric patients with asthma. But their rare and potential side effects such as hallucinations should not be forgotten especially in pediatric cases. In allergic patients with the triggering of allergen exposure some inflammatory cytokines and chemokines are released and they activate the hypothalamo-pituitary-adrenal axis and release the neuro metabolites. These metabolites also cause depression, suicide and other behavioral disorders. Additional to this mechanism, psychiatric side effects of leukotrien receptor antagonists used in the treatment of pediatric cases with asthma also potentialize this situation. So it is important to observe pediatric cases closely before and during this treatment.


References

  1. Kocyigit A, Oksuz GB, Yarar F, Uzun F, Igde M, Islek I. Hallucination development with montelukast in a child with asthma: case presentation. Iran J Allergy Asthma Immunol 2013 Aug 28;12(4):397-9.
  2. Igde M, Anlar FY. The efficacy of montelukast monotherapy in moderate persistent asthmatic children. Iran J Allergy Asthma Immunol 2009; 8(3):169-70.
  3. Wallerstedt SM, Brunlöf G, Sundström A, Eriksson AL. Montelukast and psychiatric disorders in children. Pharmacoepidemiol Drug Saf 2009; 18(9):858- 64.
  4. Anandan N, Ibitoye F. Montelukast and worsening of hallucinations in paranoid schizophrenia. The Psychiatrist. 2008; 32:276.

 

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