Allergy

2016

 

 

2015

1. Biomarkers of Oxidative Stress in Acute and Chronic Bronchial Asthma. J Asthma. 2014 Aug;51(6):578-84.

3. Prevention of intestinal allergy in mice by rflaA: Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC. PLoS One. 2014 Feb 7;9(2):e87822.

5. Evaluation of two commercial omalizumab/free IgE immunoassays: implications of use during therapy. Curr Med Res Opin. 2014 May;30(5):913-22.

7. Misidentification of airflow obstruction: prevalence and clinical significance in an epidemiological study. Int J Chron Obstruct Pulmon Dis. 2015 Mar;10:535-40.

9. Expression of genes related to anti-inflammatory pathways are modified among farmers’ children. PLoS One. 2014 Mar 6;9(3):e91097.

DR fig310. Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma. Am J Respir Cell Mol Biol. 2014 Dec;51(6):783-92.

 

12. Serum high-sensitivity C-reactive protein can be an airway inflammation predictor in bronchial asthma. Allergy Asthma Proc. 2015 Mar-Apr;36(2):e23-8.

14. Clinical Parameters vs Cytokine Profiles as Predictive Markers of IgE-Mediated Allergy in Young Children. PLoS One. 2015 Jul 27;10(7):e0132753.

16. Flavonoids for Allergic Diseases: Present Evidence and Future Perspective. Current Pharmaceutical Design. 2014;20(6):879-85.

18. C1 inhibitor function using contact-phase proteases as target: evaluation of an innovative assay. Allergy. 2015 Sep;70(9):1103-11.

19. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways. Am J Physiol-Lung Cell Mol Physiol. 2014 Mar;306(6):L476-L486.

Fig.1-121. Induction of Oral Tolerance with Transgenic Plants Expressing Antigens for Prevention/Treatment of Autoimmune, Allergic and Inflammatory Diseases. Curr Pharm Biotechnol. 2015;16(11):1002-11.

 

 

 

Archive

2014

2013 Nov

2013 Aug

2013 May

Anemia

2016

 

2014

 

 

Archive

2013

Autoimmune disease

2016

 

 

 

2015 Oct

1. Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nat Commun. 2015 Oct 9;6:8442.

3. Impact of metabolic syndrome on the hospitalization rate of Crohn’s disease patients seen at a tertiary care center: a retrospective cohort study. Digestion. 2015;91(3):257-62.

5. Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis. Exp Dermatol. 2015 Jul;24(7):529-35.

7. MiR-126: a novel route for natalizumab action?  Mult Scler. 2014 Sep;20(10):1363-70.

9. Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity. Journal of Theoretical Biology. 2015 Jun 21;375:95-100.

 

 

ARCHIVE

 

BREAKING NEWS: Editors’ Picks

 

Cancer

2016 Dec

1. Impact of the New Jersey Breast Density Law on Imaging and Intervention Volumes and Breast Cancer Diagnosis. J Am Coll Radiol. 2016 Oct;13(10):1189-1194.

3. The Bisphenol A analogue Bisphenol S binds to K-Ras4B – implications for ‘BPA-free’ plastics. FEBS Letters. 2016 Feb;590(3):369–375.

5. Evaluation of different extraction methods from pomegranate whole fruit or peels and of the antioxidant and antiproliferative activity of the polyphenolic fraction. Food Chem. 2016 Jul;202:59-69

7. Cigarette smoke-induced reduction in binding of the salivary translocator protein is not mediated by free radicals. Biochimie. 2016 Feb;121:1-4.

LT fig19. How Intrinsic Molecular Dynamics Control Intramolecular Communication in the Signal Transducers and Activators of Transcription Factor STAT5. PLoS ONE. 2015 December; 10(12) : e0145142.

 

12. Discovery bioanalysis and in vivo pharmacology as an integrated process: a case study in oncology drug discovery. Bioanalysis. 2016 Jul;8(14):1481-98.

15. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules. 2016 Jun 22;21(6).

16. Histone Methylation by Temozolomide; A Classic DNA Methylating Anticancer Drug. Anticancer Res. 2016 Jul;36(7):3289-99.

18. Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies. Toxicol Res.2016 5(2):407-419.

20. Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity. PLoS One. 2016 Sep 9;11(9):e0162472.

21. Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity. Immunol Lett. 2016 Aug;176:1-7.

23. Role of Histological Regression Grade after two Neoadjuvant Approaches with or without Radiotherapy in Locally Advanced Gastric Cancer. Br J Cancer. 2016 Sep 6;115(6):655-63.

25. Two-dimensional in vivo rectal dosimetry using an endorectal balloon with unfoldable radiochromic film during prostate cancer radiotherapy. Radiotherapy and Oncology 120 (2016) 327–332.

 

 

 

2. Effect of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors on colorectal cancer incidence and its precursors. Eur J Clin Pharmacol. 2016 Aug;72(8):1013-23.

4. Mucorales-Specific T Cells in Patients with Hematologic Malignancies. PLoS One. 2016 Feb 12;11(2):e0149108.

6. Improved Treatment of MT-3 Breast Cancer and Brain Metastases in a Mouse Xenograft by LRP-Targeted Oxaliplatin Liposomes. J Biomed Nanotechnol.2016 Jan;12(1):56-68

8. Low doses of gamma irradiation potentially modifies immunosuppressive tumor microenvironment by retuning tumor-associated macrophages: lesson from insulinoma. Carcinogenesis. 2016 Mar;37(3):301-13.

10. Combating autophagy is a strategy to increase cytotoxic effects of novel ALK inhibitor entrectinib in neuroblastoma cells. Oncotarget. 2016 Feb 2; 7(5): 5646–5663.

11. An optimized approach in the synthesis of imatinib intermediates and analogues. RSC Adv.2016 6(66):61458-61467.

13. Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery. J Biomed Opt. 2016 May 1;21(5):50502.

14. L-carnosine dipeptide overcomes acquired resistance to 5-fluorouracil in HT29 human colon cancer cells via downregulation of HIF1-alpha and induction of apoptosis. Biochimie. 2016 Aug;127:196-204.

17. Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma. Oncotarget. 2016 May 23. doi: 10.18632/oncotarget.9554.

19. Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner. Biochem Biophys Res Commun. 2016 Sep 16;478(2):976-81.

22. Constructing and validating 3D-pharmacophore models to a set of MMP-9 inhibitors for designing novel anti-melanoma agents. Molecular Informatics, 2016 Jul;35(6-7):238-252.

24. Molecularly determined total tumour load in lymph nodes of stage I-II colon cancer patients correlates with high-risk factors. A multicentre prospective study. Virchows Arch.2016 Oct;469(4):385-94.

26. IMRT/VMAT for malignancies in the head-and-neck region : Outcome in patients aged 80. Strahlenther Onkol. 2016 Aug;192(8):526-36.

 

 

 

2016 Apr-May

1. The Efficacy of Continued Sorafenib Treatment after Radiologic Confirmation of Progressive Disease in Patients with Advanced Hepatocellular Carcinoma. PLoS One. 2016 Jan 8;11(1):e0146456.

3. Targeting hedgehog signalling by arsenic trioxide reduces cell growth and induces apoptosis in rhabdomyosarcoma. Int J Oncol. 2016 Feb;48(2):801-12.

5. Evaluation of the local dose enhancement in the combination of proton therapy and nanoparticles. Med Phys. 2015 Nov;42(11):6703-10.

7. Current methods for the synthesis of homogeneous antibody-drug conjugates. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):775-84.

9. XPD, APE1, and MUTYH polymorphisms increase head and neck cancer risk: effect of gene-gene and gene-environment interactions. Tumour Biol. 2015 Sep;36(10):7569-79.

11. Increased risk of male cancer and identification of a potential prostate cancer cluster region in BRCA2. Acta Oncol. 2016 Jan;55(1):38-44.

14. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nat Med. 2015 Nov;21(11):1318-25.

16. Nanoassemblies Based on Supramolecular Complexes of Nonionic Amphiphilic Cyclodextrin and Sorafenib as Effective Weapons to Kill Human HCC Cells. Biomacromolecules 2015, 16, 3784−3791

18. Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. Toxicol Lett. 2016 Jan 22;241:19-31

19. Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. J Biol Inorg Chem. 2015 Oct;20(7):1205-17

21. HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif. Oncotarget. 2015 Dec 15;6(40):42838-53

23. A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer. J Biol Chem. 2016 Feb 19;291(8):4166-77.

25. Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process. ACS Nano. 2016 Feb 23;10(2):2549-58.

27. Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone. Int J Oncol. 2016 Mar;48(3):1258-70.

29. Soluble arabinoxylan enhances large intestinal microbial health biomarkers in pigs fed a red meat-containing diet. Nutrition. 2015 Apr 32(4):491-497

 

2. Analysis of Residual DSBs in Ataxia-Telangiectasia Lymphoblast Cells Initiating Apoptosis. BioMed Research International.2016, Article ID 8279560

4. Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation. J Histochem Cytochem. 2016 Jan;64(1):7-17.

6. What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PLoS One. 2016 Jan 8;11(1):e0146052.

8. Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides. J Immunol Res. 2015;2015:856340.

10. DHA-induced stress response in human colon cancer cells – Focus on oxidative stress and autophagy. Free Radic Biol Med.2016 Jan;90:158-172

12. The human antibody fragment DIATHIS1 specific for CEACAM1 enhances natural killer cell cytotoxicity against melanoma cell lines in vitro. J Immunother. 2015 Nov-Dec;38(9):357-70.

15. Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. Toxicol Pathol. 2015 Aug;43(6):852-64.

fig117. Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells. Eur J Cell Biol. 2015 Dec;94(12):653-60.

 

20.WNT/β-catenin signaling pathway and downstream modulators in low- and high-grade glioma. Cancer Genomics & Proteomics. 2016 01-02;13(1): 31-46.

22. Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression. ACS Med Chem Lett. 2015 Nov 10;7(1):28-33

24. One-Year Outcome Comparison of Laparoscopic, Robotic, and Robotic Intrafascial Simple Prostatectomy for Benign Prostatic Hyperplasia. J Endourol. 2016 Mar;30(3):312-8.

26. Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer. Stem Cells. 2015 Jul;33(7):2114-25.

28. Synthesis and anticancer evaluation of spermatinamine analogues. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1629-32.

30. Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01. PLoS One. 2016 Feb 17;11(2):e0148685.

 

 



BREAKING NEWS: Editors’ Picks

  • Acquisition of Portal Venous Circulating Tumor Cells From Patients With Pancreaticobiliary Cancers by Endoscopic Ultrasound. Gastroenterology, November 23, 2015
    New test may improve diagnosis, treatment of pancreactic cancers: Collecting blood samples from the portal vein can provide much more information about pancreatic cancer than taking blood from vein in the arm. Researchers found circulating tumors cells in 100 percent of 18 patients with suspected tumors in the pancreas and bile ducts.
  • Arthritis drug could be used to treat blood cancer sufferers. PLOS ONE, July 5, 2015
    Methotrexate (MTX) can work in the same way as the drug Ruxolitinib, but is one thousandth of the cost.
  • Immune Cells and Virus Team Up to Fight Cancer. Science Translational Medicine, March 5, 2014.
    The findings demonstrate that localized therapy with oncolytic NDV induces inflammatory immune infiltrates in distant tumors, making them susceptible to systemic therapy with immunomodulatory antibodies, which provides a strong rationale for investigation of such combination therapies in the clinic.
  • New leukemia immune cell therapy shows promise. Science Translational Medicine, February 19, 2014:
    In the latest and largest clinical study yet conducted in patients with advanced leukemia, 14 of the 16 patients – that is 88% – treated with genetically modified versions of their own immune cells, achieved complete remission, at least in the short term.
  • The PRKC1 and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma. Cancer Cell, February 10, 2014.
    PKC1 and SOX2 are genetically, biochemically, and functionally linked in LSCC, and together they drive tumorigenesis by establishing a cell-autonomous Hh signaling axis.
  • UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma. Cancer Cell, January 30, 2014
    Overexpression of UHRF1, a critical DNA methylation regulator, in zebrafish causes DNA hypomethylation, p53-mediated senescence, and hepatocellular carcinoma (HCC) when senescence is bypassed. UHRF1 overexpression is a mechanism underlying DNA hypomethylation in cancer cells and that senescence is a primary means of restricting tumorigenesis due to epigenetic disruption.
  • Molecular Engines Star in New Model of DNA Repair. Nature, January 16, 2014.
    UvrD is a transcription elongation factor that binds RNA polymerase and promotes its backwards movement when it becomes stalled at a lesion. NusA, another elongation factor, assists in promoting backtracking and helps UvrD to target other nucleotide excision repair factors to the exposed lesion.The result: fewer mutations and consequently less cancer and other kinds of disease.

Cardiovascular Disease

 

2016 Dec

2016 Aug

1. Risk of ischemic stroke during the initiation period of α-blocker therapy among older men. CMAJ. 2016 Mar 1;188(4):255-60.

3. Placental Growth Factor as a Predictor of Cardiovascular Events in Patients with CKD from the NARA-CKD Study. J Am Soc Nephrol. 2015 Nov;26(11):2871-81.

5. L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-)(/-) transgenic mice expressing CETP. Atherosclerosis. 2016 Jan;244:29-37.

7. An antihypertensive opioid: Biphalin, a synthetic non-addictive enkephalin analog decreases blood pressure in spontaneously hypertensive rats. Pharmacol Rep. 2016 Feb;68(1):51-5

9. A Cluster-Randomized, Controlled Trial of a Simplified Multifaceted Management Program for Individuals at High Cardiovascular Risk (SimCard Trial) in Rural Tibet, China, and Haryana, India. Circulation. 2015 Sep 1;132(9):815-24.

11. Study of the effects of a diet supplemented with active components on lipid and glycemic profiles. Nutrition. 2015 Jan;31(1):180-6.

14. Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals. J Clin Biochem Nutr. 2015 Sep;57(2):151-5.

16. The Angiosome Concept Evaluated on the Basis of Microperfusion in Critical Limb Ischemia Patients-an Oxygen to See Guided Study. Microcirculation. 2015 Nov;22(8):737-43.

18. Cardiac Myxoma With Unusual Obstructive and Embolic Presentations: Concurrent Stroke and Angiography-Negative Myocardial Infarction–A Case Report. Medicine. 2015 Sep;94(38):e1602.

20. Shell matters: Magnetic targeting of SPIONs and in vitro effects on endothelial and monocytic cell function. Clin Hemorheol Microcirc. 2015;61(2):259-77.

22. Problem-Solving Therapy During Outpatient Stroke Rehabilitation Improves Coping and Health-Related Quality of Life: Randomized Controlled Trial. Stroke. 2016 Jan;47(1):135-42.

24. Effect of diagnosis with a chronic disease on physical activity behavior in middle-aged women. Prev Med. 2016 Feb;83:56-62.

 

 

2. Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats. Biol Pharm Bull. 2015;38(12):1879-90.

4. Incremental cost-effectiveness of dobutamine stress cardiac magnetic resonance imaging in patients at intermediate risk for coronary artery disease. Clin Res Cardiol. 2015 May;104(5):401-9.

6. Role of cerebellar adrenomedullin in blood pressure regulation. Neuropeptides. 2015 Dec;54:59-66.

8. Endogenous Ouabain: An Old Cardiotonic Steroid as a New Biomarker of Heart Failure and a Predictor of Mortality after Cardiac Surgery. Biomed Res Int. 2015;2015:714793.

10. Antifungal-Associated Drug-Induced Cardiac Disease. Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S662-8.

12. TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells. PLoS ONE. 2015 Dec 28;10(12):e0145523.

15. Summer syncope syndrome redux. Am J Med. 2015 Oct;128(10):1140-3.

17. Type 2 Iodothyronine Deiodinase Activity Is Required for Rapid Stimulation of PI3K by Thyroxine in Human Umbilical Vein Endothelial Cells. Endocrinology. 2015 Nov;156(11):4312-24.

19. Vascular Repair by Tissue-Resident Endothelial Progenitor Cells in Endotoxin-Induced Lung Injury. Am J Respir Cell Mol Biol. 2015 Oct;53(4):500-12.

Picture221. Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats. Biomed Res Int. 2015;2015:753210

 

23. Dipstick proteinuria as a predictor of all-cause and cardiovascular disease mortality in Bangladesh: A prospective cohort study. Prev Med. 2015 Sep;78:72-7.

25. Cotinine as a marker for risk prediction in the Ludwigshafen Risk and Cardiovascular Health Study. Respir Physiol Neurobiol. 2015 Apr;209:17-22.

 

 

2015 Nov-Dec
 

 

 

 

BREAKING NEWS: Editors’ Picks

 

Diabetes and Obesity

2016 Dec

2. Knockdown expression of Syndecan in the fat body impacts nutrient metabolism and the organismal response to environmental stresses in Drosophila melanogaster. Biochem Biophys Res Commun. 2016 Aug 12;477(1):103-8.

4. Biomolecular Characterization of Putative Antidiabetic Herbal Extracts. PLoS One. 2016 Jan 28;11(1):e0148109.

6. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Res. 2016 Jul;26(7):787-804.

8. Association of endothelial proliferation with the magnitude of weight loss during calorie restriction. Angiogenesis. 2016 Jul;19(3):407-19.

10. Utilizing Genomics through Family Health History with the Theory of Planned Behavior: Prediction of Type 2 Diabetes Risk Factors and Preventive Behavior in an African American Population in Florida. Public Health Genomics. 2016;19(2):69-80.

12. Child dietary and eating behavior outcomes up to 3.5 years after an early feeding intervention: The NOURISH RCT. Obesity. 2016 Jul;24(7):1537-45.

15. Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. Exp Biol Med. 2016 Apr;241(8):817-29.

18. Lean mass predicts conditioned pain modulation in adolescents across weight status. European Journal of Pain. 2016 Jul; 20(6): 967-976.

20. Outcomes and healthcare resource utilization associated with medically attended hypoglycemia in older patients with type 2 diabetes initiating basal insulin in a US managed care setting. Curr Med Res Opin. 2016 Sep;32(9):1557-65.

 

2016 Apr-June

1. Ghrelin O-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet. J Endocrinol. 2016 228(2):115-125

3. Combining citrulline to atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity. Br J Pharmacol. 2015 Oct;172(20):4996-5008.

5. Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight. Sleep. 2015 Dec 1;38(12):1893-903

7. Incidence and care-related costs of severe hypoglycaemia requiring emergency treatment in Andalusia (Spain): the PAUEPAD project. Diabet Med. 2015 Nov;32(11):1520-6.

9. The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis. J Mol Endocrinol. 2015 Jun;54(3):227-39.

11. Visceral fat is better related to impaired glucose metabolism than body mass index after kidney transplantation. Transpl Int. 2015 Oct;28(10):1162-71.

14. Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs. Exp Physiol. 2016 Jan 1;101(1):100-12.

16. A Comparison of the Effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters: A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2). PLoS One. 2015 Aug 18;10(8):e0135854.

18. Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats. Biomed Res Int. 2015;2015:214918.

20. Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism. British Journal of Nutrition 2015 Nov 14;114(9):1410-18.

22. Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy. J Neurosurg Spine. 2015 Dec;23(6):707-14

24. Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner. J Biol Chem. 2015 Dec 18;290(51):30514-29.

26. Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients. Am J Physiol Renal Physiol. 2016 Mar 1;310(5):F416-25.

28. The Application of Systems Science to Addressing Obesity at the Workplace: Tapping into Unexplored Potential. J Occup Environ Med. 2016 Feb;58(2):123-6.

 

 

2. Using synchronous distance education to deliver a weight loss intervention:  a randomized trial. Obesity. 2016 Jan;24(1):44-50

4. Multicenter investigation of lifestyle-related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age. Birth Defects Res A Clin Mol Teratol. 2015 Sep;103(9):787-93.

6. Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota. Metabolism. 2016 Jan;65(1):48-65.

8. Disturbance of the intestinal microbial community by ursolic acid contributes to its function as a regulator of fat deposition. J Funct Food.2015 Apr;14:456-468.

10. GLP-2 as Beneficial Factor in the Glucose Homeostasis in Mice Fed a High Fat Diet. J Cell Physiol. 2015 230(12):3029-3036.

12. Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. J Biol Chem. 2015 Oct 16;290(42):25475-86.

15. Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright? Curr Pharm Des. 2015;21(33):4917-35.

17. Chronic Co-Administration of Sepiapterin and l-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice. Circ Heart Fail. 2016 Jan;9(1):e002424.

19. Results of Automated Retinal Image Analysis for Detection of Diabetic Retinopathy from the Nakuru Study, Kenya. PLoS One. 2015 Oct 1;10(10):e0139148.

21. The Diabetes Visual Function Supplement Study (DiVFuSS). Br J Ophthalmol. 2016 Feb;100(2):227-34.

23. Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients. PLoS One. 2016 Mar 1;11(3):e0150154.

25. Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice. FASEB J. 2016 Feb;30(2):775-84.

27. Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway. J Diabetes Res. 2016;2016:9128050.

29. Integrating palliative care with usual care of diabetic foot wound. Diabetes Metab Res Rev. 2016 Jan;32 Suppl 1:303-10.

30. The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats. J Diabetes Res. 2016;2016:8178936.

 

 

BREAKING NEWS: EDITORS’ PICKS

  • The Major Link Between Obesity and Diabetes. From Dr. Louis Venter. May 6, 2016 
  • Leptin plays a direct role in cardiovascular disease in obesity. Circulation, October 7, 2015
    While high levels of the satiety hormone leptin don’t help obese individuals lose weight, they do appear to directly contribute to their cardiovascular disease.
  • Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. PNAS, 2015 Sept
    As obesity rates for pregnant women continue to climb, scientists have discovered that increasing a specific hormone during pregnancy can reduce or eliminate the chances that the baby will become obese as well.
  • High dietary fiber intake linked to health promoting short chain fatty acids. Gut, September 29, 2015
    Eating a lot of fibre-rich foods, such as fruit, vegetables, and legumes–typical of a Mediterranean diet–is linked to a rise in health promoting short chain fatty acids (SCFAs), which include acetate, propionate, and butyrate, are produced by bacteria in the gut during fermentation of insoluble fibre from dietary plant matter. SCFAs have been linked to health promoting effects, including a reduced risk of inflammatory diseases, diabetes, and cardiovascular disease.
  • Progress of Diabetic Severity and Risk of Dementia. Journal of Clinical Endocrinology & Metabolism, July 9, 2015
    People who have diabetes and experience high rates of complications are more likely to develop dementia as they age than people who have fewer diabetic complications.
  • Measuring kidney health could better predict heart disease risk. Lancet Diabetes and Endocrinology. May 29, 2015
    Simple measures of kidney function and damage may be just as good at predicting who is at risk for heart failure and death from heart attack and stroke as traditional tests of cholesterol levels and blood pressure, new research suggests.
  • Genetically elevated triglyceride level associated with protection against type 2 diabetes. PLOS Genetics, May 28, 2015
    It demonstrates that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. The studied genes therefore appear to both increase triglyceride levels and decrease type-2 diabetes risk. Although no single gene appeared to be driving this trend, several, including a variant near the APOA1 gene, stood out as potentially interesting to this finding.
  • Diabetes debate: Triglycerides form in liver despite insulin resistance. PNAS, January 5, 2015
    Triglycerides are produced in the liver independent of insulin action in the liver, solving one of the great mysteries of type 2 diabetes.
  • Leptin also influences brain glial cells to control appetite. Nature Neuroscience, June 1, 2014
    Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, researchers have found that the hormone also acts on other types of cells, glial cells, which provide the main barrier between the periphery and the brain, and therefore could be targeted for drugs that treat metabolic disorders, including obesity and diabetes.
  • Obesity rates climbing worldwide. The Lancet, May 28, 2014
    Worldwide, there has been a startling increase in rates of obesity and overweight in both adults (28% increase) and children (up by 47%) in the past 33 years, with the number of overweight and obese people rising from 857 million in 1980 to 2.1 billion in 2013, according to a most comprehensive global study to date.

Editors’ Picks

2017 May

1. Dynamin-dependent endocytosis of Bone Morphogenetic Protein 2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling. Int J Biochem Cell Biol. 2016 Jul;76:51-63.

3. An Empirical Analysis of Life Jacket Effectiveness in Recreational Boating. Risk Anal. 2016 Feb;36(2):302-19.

5. Antioxidant potential in non-extractable fractions of dried persimmon (Diospyros kaki Thunb.). Food Chemistry. 2016 Jul; 202:99-103.

7. Differential Expression of Proteoglycans by Corneal Stromal Cells in Keratoconus. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2618-28.

9. Cloning and expression of 3-deoxy-d-manno-oct-2-ulosonic acid α-ketoside hydrolase from oyster hepatopancreas. Glycobiology. 2015 Dec;25(12):1431-40.

11. Two conformers of a tyrosine kinase inhibitor (AG-1478) disclosed using simulated UV-Vis absorption spectroscopy. New J Chem.2016, 40(10):8296-8304.

14. The naturally occurring α-tocopherol stereoisomer RRR-α-tocopherol is predominant in the human infant brain. British Journal of Nutrition, 2016; 116: 126–131.

15. Blood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields. PLoS One. 2016 Aug 18;11(8):e0161207.

17. Quantitative Comparison of the Antimicrobial Efficiency of Leaching versus Nonleaching Polymer Materials. Macromol Biosci. 2016 May;16(5):647-54.

19. Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation. Pain 2016 Jul; 157(7):1541-50.

21. ALG-2 divalent-ion affinity: Calorimetric analysis of the des23 versions reveals high-affinity site for Mg(2).Biophys Chem. 2016 Feb;209:28-40.

23. Plasmacytoid dendritic cells and memory T cells infiltrate true sequestrations stronger than subligamentous sequestrations: evidence from flow cytometric analysis of disc infiltrates. Eur Spine J 2016 25(5): 1417-1427.

25. Topical treatment with coenzyme Q10-containing formulas improves skin’s Q10 level and provides antioxidative effects. Biofactors. 2015 Nov 12; 41(6): 383–390.

27. Proteomic changes in the liver of Channa striatus in response to high temperature stress. Electrophoresis.2016 Jul;37(12):1704-1717

 

2. HMGB1 Is Increased by CFTR Loss of Function, Is Lowered by Insulin, and Increases In Vivo at Onset of CFRD. J Clin Endocrinol Metab. 2016 Mar;101(3):1274-81.

4. Binding Free Energy Calculations of Nine FDA-approved Protease Inhibitors Against HIV-1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer. Chem Biol Drug Des. 2016 Apr;87(4):487-98.

6. Hemoptysis from an aorto-pulmonary collateral vessel in a four month old resolved by embolization. Pediatr Pulmonol. 2016 Sep;51(9):E31-3.

8. Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates. Human Reproduction. 2016 July;31(7):1522-30.

10. Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus. Biomed Res Int. 2016;2016:2794096.

12. Dose of phenobarbital and age of treatment at early life are two key factors for the persistent induction of cytochrome P450 enzymes in adult mouse liver. Drug Metabolism and Disposition, 2015, 43(12):1938-1945.

16. Magnetic Resonance Imaging of Postoperative Fracture Healing Process without Metal Artifact: A Preliminary Report of a Novel Animal Model. BioMed Research International. 2016;2016:1429892.

18. Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid. Proteomics. 2016 May;16(9):1398-406.

20. Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition. J Immunol. 2016 Apr 1;196(7):3019-31.

22. Variation of DNA Fragmentation Levels During Density Gradient Sperm Selection for Assisted Reproduction Techniques: A Possible New Male Predictive Parameter of Pregnancy? Medicine. 2016 May;95(20):e3624.

24. Salting-out-assisted liquid-liquid extraction as a suitable approach for determination of methoxetamine in large sets of tissue samples. Anal Bioanal Chem. 2016 Feb;408(4):1171-1181.

26. Prioritization and burden analysis of rare variants in 208 candidate genes suggest they do not play a major role in CAKUT. Kidney International. 2016 Feb;89(2):476-86.

28. The long-term clinical outcome of arrhythmogenic right ventricular cardiomyopathy subjects with a p.S358L mutation in TMEM43 after implantable cardioverter defibrillator (ICD) therapy for both primary and secondary prophylaxis. Circ Arrhythm Electrophysiol. 2016 Mar;9(3).

 

2016 Dec

1. Direct Monitoring of β-Sheet Formation in the Outer Membrane Protein TtoA Assisted by TtOmp85. Biochemistry. 2016 Aug 9;55(31):4333-43.

3. The design of empirical studies: towards a unified view. Eur J Epidemiol. 2016 Mar;31(3):217-28.

5. H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport. Biochem Biophys Res Commun. 2016 Jul 8;475(4):335-41.

7. Bismuth(III) deferiprone effectively inhibits growth of Desulfovibrio desulfuricans ATCC 27774. Biometals. 2016 Apr;29(2):311-9.

8. Porphyromonas gingivalis gingipain-dependently enhances IL-33 production in human gingival epithelial cells. PLoS ONE. 2016 Apr; 11(4):e0152794.

10. Exposure of the grass shrimp, Palaemonetes pugio, to antimicrobial compounds affects associated Vibrio bacterial density and development of antibiotic resistance. Environ Toxicol. 2016 Apr;31(4):469-77.

12. Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia. Heart Vessels. 2016 May;31(5):713-21.

15. Studying small molecule-aptamer interactions using MicroScale Thermophoresis (MST). Methods. 2016 Mar 15;97:27-34.

17. Does Greater Continuity of Veterans Administration Primary Care Reduce Emergency Department Visits and Hospitalization in Older Veterans? J Am Geriatr Soc. 2015 Dec;63(12):2510-2518.

19. The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice. Regul Toxicol Pharmacol. 2016 Jul;78:1-7.

21. A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia. J Psychopharmacol. 2016 May;30(5):428-35.

25. Variable Wettability Control of a Polymer Surface by Selective Ultrasonic Imprinting and Hydrophobic Coating. Colloid Polym Sci.2016 Sep;294(9):1413-1423.

27. A new oxygen modification cyclooctaoxygen binds to nucleic acids as sodium crown complex. Biochim Biophys Acta. 2016 Apr;1860(4):785-94.

29. Oxygen Monitoring Reduces the Risk for Retinopathy of Prematurity in a Mexican Population. Neonatology. 2016;110(2):135-40.

 

2. Pharmacokinetics, Pharmacodynamics, and Safety of Single-Dose Rivaroxaban in Chronic Hemodialysis. Am J Nephrol. 2016;43(4):229-36.

4. Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells. Genes Cells. 2016 Aug;21(8):861-73.

6. Analysis of seroprevalence against Coxiella burnetii in a sample of farm workers in Western Sicily. Ann Agric Environ Med. 2016;23(1):71-4.

9. VH and VL Domains of Polyspecific IgM and Monospecific IgG Antibodies Contribute Differentially to Antigen Recognition and Virus Neutralization Functions. Scand J Immunol. 2016 Jul;84(1):28-38.

11. Targeting the Achilles‘ heel of adult living donor liver transplant: Corner-sparing sutures with mucosal eversion technique of biliary anastomosis. Liver Transpl. 2016 Jan;22(1):14-23.

14. Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation. Neuroendocrinology. 2016;103(5):605-15.

16. Adenosine hypothesis of antipsychotic drugs revisited: pharmacogenomics variation in nonacute schizophrenia. OMICS. 2016 May;20(5):283-9.

18. Supercritical fluid extraction from microalgae with high content of LC-PUFAs. A case of study: Sc-CO2 oil extraction from Schizochytrium sp. J Supercrit Fluids. 2016 Oct; 116:126-131.

20. On a path to accelerate access to Ebola vaccines: The WHO’s research and development efforts during the 2014-2016 Ebola epidemic in West Africa. Curr Opin Virol. 2016 Apr;17:138-44.

22. The Effect of Pressure-Controlled Ventilation and Volume-Controlled Ventilation in Prone Position on Pulmonary Mechanics and Inflammatory Markers. Inflammation. 2016 Aug;39(4):1469-74.

23. Synchronous Bioimaging of Intracellular pH and Chloride Based on LSS Fluorescent Protein. ACS Chem Biol. 2016 Jun 17;11(6):1652-60.

26. Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F. Pediatrics. 2016 Sep;138(3). pii: e20153036.

28. Quantitative risk assessment on the dietary exposure of Finnish children and adults to nitrite. Food Additives & Contaminants: Part A. 2016; 33:1, 41-53.

 

 

 

Infection and Immunity

2016 Dec

1. Capsule Design for Blue Light Therapy against Helicobacter pylori. PLoS One. 2016 Jan 27;11(1):e0147531.

3. An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection. PLoS One. 2016 Feb 12;11(2):e0148824.

5. Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin in cirrhosis after complete destruction of hepatocellular carcinoma. World J Gastroenterol. 2016 Feb 28;22(8):2630-5.

7. Validation of research trajectory 1 of an Exposome framework: Exposure to benzo(a)pyrene confers enhanced susceptibility to bacterial infection. Environ Res. 2016 Apr;146:173-84.

9. Clinical Outcomes of Patients with HIV Undergoing Lead Extraction for Infectious and Noninfectious Indications. Pacing Clin Electrophysiol. 2016 Feb;39(2):122-7.

11. Persistence of non-typeable Haemophilus influenzae in the pharynx of children with adenotonsillar hypertrophy after treatment with azithromycin. Pathogens and Disease. 2016 Feb;74(1):ftv106.

14. Development of an in vitro model of the early-stage bovine tuberculous granuloma using Mycobacterium bovis-BCG. Vet Immunol Immunopathol. 2015 Dec 15;168(3-4):249-57.

15. Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies. AIDS Res Hum Retroviruses. 2016 Feb;32(2):178-86.

17. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID “Meet the Experts” 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19.

19. “My Favourite Day Is Sunday”: Community Perceptions of (Drug-Resistant) Tuberculosis and Ambulatory Tuberculosis Care in Kara Suu District, Osh Province, Kyrgyzstan. PLoS One. 2016 Mar 28;11(3):e0152283.

21. Emergence of reticuloendotheliosis virus in pigeons in Guangdong province, southern China. Arch Virol. 2016 Jul;161(7):2007-2011.

23. Nonactivated Protein C in the Treatment of Neonatal Sepsis: A Retrospective Analysis of Outcome. Pediatr Infect Dis J. 2016 Sep;35(9):967-71.

25. The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. PLoS One. 2016 Jul 26;11(7):e0159324.

27. Antigen Receptor-Intrinsic Non-Self: The Key to Understanding Regulatory Lymphocyte-Mediated Idiotypic Control of Adaptive Immune Responses. Crit Rev Immunol. 2016;36(1):13-56.

 

 

2. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. Biomed Res Int. 2016;2016:7985104.

4. Detection of natural infection of Leishmania donovani (Kinetoplastida: Trypanosomatidae) in Phlebotomus argentipes (Diptera: Psychodidae) from a forest ecosystem in the Western Ghats, India, endemic for cutaneous leishmaniasis. Acta Trop. 2016 Apr;156:95-9.

6. Social class based on occupation is associated with hospitalization for A(H1N1)pdm09 infection. Comparison between hospitalized and ambulatory cases. Epidemiol Infect. 2016 Mar;144(4):732-40.

8. Efficacy and persistent activity of moxidectin against natural Muellerius capillaris infection in goats and pathological consequences of muelleriosis. Vet Parasitol. 2016 Mar 15;218:98-101.

10. Neutrophil-to-lymphocyte ratio in the differential diagnosis of acute bacterial meningitis. Eur J Clin Microbiol Infect Dis 2016 Mar; 35(3):397-403.

12. A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Properties and Characterization of the Protein. PLoS One. 2015 Nov 5;10(11):e0140994.

16. Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii. J Biol Chem. 2013 Sep 20;288(38):27002-18.

18. Spondylodiscitis severity code: scoring system for the classification and treatment of non-specific spondylodiscitis. Eur Spine J. 2016 Apr;25(4):1012-20.

20. TLR4 induces CCR7-dependent monocytes transmigration through the blood-brain barrier. J Neuroimmunol. 2016 Jun 15;295-296:12-7.

22. PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells. Mediators Inflamm. 2016;2016:9605253.

24. Modeling and predicting drug resistance rate and strength. Eur J Clin Microbiol Infect Dis.2016 Aug;35(8):1259-1267.

26. Analysis of the beta-propiolactone sensitivity and optimization of inactivation methods for human influenza H3N2 virus. J Virol Methods.2016 Sep;235:105-111

 

 



BREAKING NEWS: EDITORS’ PICKS

New analysis of the influenza A virus shows potential for developing new anti-viral drugs which are more likely to be universally effective against the flu virus originating from avian, swine or human virus strains.

Around 1 in 5 of the population were infected in both recent outbreaks of seasonal flu and the 2009 H1N1 influenza pandemic, but just 23% of these infections caused symptoms, and only 17% of people were ill enough to consult their doctor.

One person having a rare combination of both lupus and HIV, has the unique ability to fight HIV. This provided key insights into an immune response that researchers now hope to trigger with a vaccine, according to new findings.

The immune cells of 12 HIV positive patients have been successfully genetically engineered by researchers to resist infection, and decrease the viral loads of some patients taken off antiretroviral drug therapy (ADT) entirely -— including one patient whose levels became undetectable. This it the first published report of any gene editing approach in humans.

A KwaZulu-Natal woman’s body responded to her HIV infection by making potent antibodies (called broadly neutralizing antibodies, because they are able to kill multiple strains of HIV from across the world). Researchers identified these antibodies in her blood and then duplicated them by cloning the antibodies in the laboratory. The cloned antibodies were then used in a series of experiments in the laboratory to elucidate the pathway followed by her immune system to make these potent antibodies.

The antibiotics, called spectinamides, were created by changing the chemical structure of an existing antibiotic, spectinomycin, which does not work against TB.

 

Musculoskeletal Disorder

 

Osteoporosis 2016

 

 

Arthritis 2016

 

 

Osteoporosis 2015 Oct

 

 

Arthritis 2015 Sept

 

BREAKING NEWS: Editors’ Picks

 

 

 

Neuroscience

2016 Oct-Dec

 

 

2016 Sept

1. Normative data for subcortical regional volumes over the lifetime of the adult human brain. Neuroimage. 2016 Aug 15;137:9-20.

3. Does vigabatrin treatment for infantile spasms cause visual field defects? An international multicentre study. Dev Med Child Neurol. 2015 Jan;57(1):60-7.

5. Evidence of motor-control difficulties in children with attention deficit hyperactivity disorder, explored through a hierarchical motor-systems perspective. J Clin Exp Neuropsychol. 2016;38(2):183-96.

7. Influence of workspace constraints on directional preferences of 3D arm movements. Exp Brain Res. 2015 Jul;233(7):2141-53.

9. Complementary assessments of executive function in preterm and full-term preschoolers. Child Neuropsychol. 2015;21(3):331-53.

11. Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker. Int J Neuropsychopharmacol. 2015 Mar 26;18(10):pyv038.

14. The role of the acidic domain of α-synuclein in amyloid fibril formation: a molecular dynamics study. J Biomol Struct Dyn. 2016;34(2):376-83.

16. Dexmedetomidine attenuates neurotoxicity induced by prenatal propofol exposure. J Neurosurg Anesthesiol. 2016 Jan; 28(1):51-64.

18. Neural responses towards a speaker’s feeling of (un)knowing. Neuropsychologia. 2016 Jan 29;81:79-93.

20. Development and preliminary validation of an Observation List for detecting mental disorders and social Problems in the elderly in primary and home care (OLP). Int J Geriatr Psychiatry. 2016 Jul;31(7):755-64.

22. The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system. Physiol Meas. 2016 May;37(5):649-60.

24. The role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UK. Int J Geriatr Psychiatry. 2016 Jun;31(6):601-10.

25. Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies. Neuroscience. 2016 Jul 22;328:165-83.

27. Dramatic Response After Lamotrigine in a Patient With Epileptic Encephalopathy and a De NovoCACNA1A Variant. Pediatr Neurol. 2016 Jul;60:79-82.

 

2. Changes in the BDNF-immunopositive cell population of neocortical layers I and II/III after focal cerebral ischemia in rats. Brain Res. 2015 Apr 24;1605:76-82.

4. Altered top-down cognitive control and auditory processing in tinnitus: evidences from auditory and visual spatial stroop. Restor Neurol Neurosci. 2015 Jan; 33(1):67-80.

6. Sub-hubs of baseline functional brain networks are related to early improvement following two-week pharmacological therapy for major depressive disorder. Hum Brain Mapp. 2015 Aug;36(8):2915-27.

8. Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009-2011. Am J Epidemiol. 2015 Sep 15;182(6):512-9.

10. NEFL N98S mutation: another cause of dominant intermediate Charcot-Marie-Tooth disease with heterogeneous early-onset phenotype. Journal of Neurology 2016 Feb; 263(2): 361-9

12. Interferon-Stimulated Gene 15 Upregulation Precedes the Development of Blood-Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Young Mice. J Neurotrauma. 2015 Jul 15;32(14):1101-8.

15. Attention that covers letters is necessary for the left-lateralization of an early print-tuned ERP in Japanese hiragana. Neuropsychologia. 2015 Mar;69:22-30.

17. Brain activities of visual thinkers and verbal thinkers: A MEG study. Neurosci Lett. 2015 May 6;594:155-160.

19. mRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. J Mol Neurosci. 2016 Apr;58(4):411-5.

21. Dynamical Behavior of Human α-Synuclein Studied by Quasielastic Neutron Scattering. PLoS One. 2016 Apr 20; 11(4): e0151447.

23. Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol. 2016 Aug;81:65-75.

26. Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars. Neurodegener Dis. 2016;16(3-4):245-59.

2016 Aug

1. Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A. Eur J Neurosci. 2015 Sep;42(6):2356-70.

3. Isoallopregnanolone antagonize allopregnanolone-induced effects on saccadic eye velocity and self-reported sedation in humans. Psychoneuroendocrinology. 2015 Feb;52:22-31.

5. Dysfunction in ribosomal gene expression in the hypothalamus and hippocampus following chronic social defeat stress in male mice as revealed by RNA-Seq. Neural Plast. 2016;2016:3289187.

7. Disinhibition reduces extracellular glutamine and elevates extracellular glutamate in rat hippocampus in vivo. Epilepsy Res. 2015 Aug;114:32-46.

9. Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies. Cell Mol Neurobiol. 2015 Jan;35(1):57-70.

11. Near-transfer effects following working memory intervention (Cogmed) in children with symptomatic epilepsy: An open randomized clinical trial. Epilepsia. 2015 Nov;56(11):1784-92.

14. Can impaired working memory functioning be improved by training? – A meta-analysis with a special focus on brain injured patients. Neuropsychology (2016) Feb;30(2):190-212.

16. Prevalence and etiology of epilepsy in a Norwegian county – a population based study. Epilepsia. 2015 May;56(5):699-706.

17. Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits. Neuropsychopharmacology. 2015 Aug;40(9):2175–84.

19. The long-term impact of early life poverty on orbitofrontal cortex volume in adulthood: results from a prospective study over 25 years. Neuropsychopharmacology. 2015 Mar;40(4):996-1004.

21. Is a neuronal chain between the pineal body and the retina in rats and hamsters? Transneural tracing studies. Neurosci Lett. 2015 Feb 19;588:1-6.

23. Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis. Biophys J. 2015 Apr 21;108(8):2038-47.

25. Transplantation of neural progenitor cells in chronic spinal cord injury. Neuroscience. 2016 Apr 21;320:69-82.

27. Childhood-onset epilepsy five decades later. A prospective population-based cohort study. Epilepsia. 2015 Nov;56(11):1774-83.

 

2. Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. J Neurosci. 2015 Jan 21;35(3):1211-6.

4. Aberrant Monoaminergic System in Thyroid Hormone Receptor-β Deficient Mice as a Model of Attention-Deficit/Hyperactivity Disorder. Int J Neuropsychopharmacol. 2015 Jan 22;18(7):pyv004.

6. Characterisation of cell-substrate interactions between Schwann cells and three-dimensional fibrin hydrogels containing orientated nanofibre topographical cues. Eur J Neurosci. 2016 Feb;43(3):376-87.

8. Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea. Eur J Neurosci. 2015 Aug;42(3):1984-2002.

10. Alcohol dependence and genetic variability in serotonin pathway among currently and formerly alcohol-dependent males. Neuropsychobiology. 2015;72(1):57-64.

12. Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice. J Pharm Pharmacol. 2015 Dec;67(12):1716-22.

15. Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease. Mov Disord. 2015 Jun;30(7):989-91.

18. Nap it or leave it in the elderly: A nap after practice relaxes age-related limitations in procedural memory consolidation. Neurosci Lett. 2015 Oct 8;606:173-6.

20. Mechanisms and environmental factors that underlying the intensification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced serotonin syndrome in rats. Psychopharmacology (Berl). 2015 Apr;232(7):1245-60.

22. Metabotropic Glutamate Receptor Subtype 7 in the Bed Nucleus of the Stria Terminalis is Essential for Intermale Aggression. Neuropsychopharmacology. 2016 Feb;41(3):726-35.

24. PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites. Neurosci Lett. 2015 Sep 25;605:18-23.

26. Dopamine Transporter Activity Is Modulated by α-Synuclein. J Biol Chem. 2015 Dec 4;290(49):29542-54.

 

BREAKING NEWS: Editors’ Picks

  • A new study suggests Alzheimer’s disease may come from the brain infections. Science Translational Medicine, 2016 May.
    The new study could change the way we think about the disease, and develop new drugs for treatment.
  • New Alzheimer’s disease causing proline substitutions. The EMBO Journal, Nov 3, 2015
    The failure to develop efficient Alzheimer’s therapy might come from the pooling, in clinical experiments, of patients who suffer from distinct disorders that eventually lead to Alzheimer’s symptoms. Therefore it is essential to carefully characterize and classify the mechanisms that underlie Alzheimer’s disease, in order to allow for the development of novel therapies.
  • Modulating brain’s stress circuitry might prevent alzheimer’s disease. Alzheimer’s & Dementia, Nov 16, 2015.
    long-term treatment using a small molecule drug that reduces activity of the brain’s stress circuitry significantly reduces Alzheimer’s disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.
  • Alzheimer protein’s structure may explain its toxicity. Nature Structural & Molecular Biology, 2015 May.
    Knowing the physical structure of the 42 amino acid-long form of amyloid beta in the fibers is key to understanding how it folds up improperly and aggregates into toxic plaques.
  • New link between diabetes and Alzheimer. Journal of Clinical Investigation, 2015 May
    A unique connection between diabetes and Alzheimer’s disease has been uncovered, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar.
  • Even mild traumatic brain injury may cause brain damage. Neurology, 2014 July.
    Those with injuries had brain damage in brain white matter consisting of disruption to nerve axons. This finding is especially important, as 90 percent of all traumatic brain injuries are mild to moderate.
  • XIAP Regulates Caspase Activity in Degenerating Axons. Cell Reports, 2013 August.
    Excessive nerve cell pruning leads to disease. Scientists have made important discoveries about a cellular process that occurs during normal brain development and may play an important role in neurodegenerative diseases. The study’s findings point to new pathways and targets for novel therapies for Alzheimer’s.
  • Prion-like proteins drive several diseases of aging. Nature, 2013 September
    A new emerging concept that many of the brain diseases associated with aging, such as Alzheimer’s and Parkinson’s, are caused by specific proteins that misfold and aggregate into harmful seeds. These seeds behave very much like the pathogenic agents known as prions, which cause mad cow disease.

 

New Technology

 

2016 Dec

1. Scattering based hyperspectral imaging of plasmonic nanoplate clusters towards biomedical applications. J Biophotonics. 2016 Jul;9(7):721-9.

3. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long-Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy. ACS Nano. 2016 Jun 28;10(6):5720-9.

5. Suppression of Immune Response to Adenovirus Serotype 5 Vector by Immunization with Peptides Containing an MHC Class II Epitope and a Thio-Oxidoreductase Motif. Hum Gene Ther. 2016 Mar;27(3):230-43.

7. Estimating the Effective Permittivity for Reconstructing Accurate Microwave-Radar Images. PLoS One. 2016 Sep 9;11(9):e0160849.

9. Cross-reactive, self-encoded polymer film arrays for sensor applications. RSC Adv.2016 6(86):82616-82624.

11. A colorimetric protease activity assay method using engineered procaspase-3 enzymes. Anal. Methods, 2016, 8, 6270-6276.

14. Mitochondrial Haplogroups and Expression Studies of commonly used Human Cell Lines. Mitochondrion. 2016 Sep;30:236-47.

16. Rapid identification of electricigens via silver-plated photonic crystal filters. Nano Res.2016 Sep;9(9):2760-2771.

18. TiO2 sol-embedded in electroless Ni-P coating: A novel approach for ultra-sensitive sorbitol sensor. RSC Advances. 2016 6(73): 69261-69269.

20. Single-step enrichment of basophils from human peripheral blood by a novel method using a Percoll density gradient. J Sep Sci. 2016 Aug;39(15):3062-71.

22. Combined Tumor– and Neovascular-“Dual Targeting” Gene/Chemo-Therapy Suppresses Tumor Growth and Angiogenesis. ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25753-25769.

24. Identification of extracellular miRNA in archived serum samples by next-generation sequencing. Mol Biol Rep. 2016 Oct; 43(10):1165-78.

 

 

2. Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections. Nanomedicine. 2016 Aug;11(16):2185-95.

4. Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer’s disease murine model. Nano Res.2016 Jul;9(7):2190-2201.

6. Peptide Tag-Induced Horseradish Peroxidase-Mediated Preparation of a Streptavidin-Immobilized Redox-Sensitive Hydrogel. Biomacromolecules. 2016 Jun 13;17(6):1978-84.

8. Microfluidic Immuno-Biochip for Detection of Breast Cancer Biomarkers Using Hierarchical Composite of Porous Graphene and Titanium Dioxide Nanofibers. ACS Appl Mater Interfaces. 2016 Aug 17;8(32):20570-82.

10. Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical Imaging. Langmuir. 2016 Aug 9;32(31):7929-42.

12. Hydrodynamic focusing for microfluidic impedance cytometry: a system integration study. Microfluid Nanofluid.2016 Sep;20(9)

15. Mono-sulfonated tetrazolium salt based NAD(P)H detection reagents suitable for dehydrogenase and real-time cell viability assays. Anal Biochem. 2016 Sep 15;509:33-40.

17. Detection of base-pair mismatches in DNA using graphene-based nanopore device. Nanotechnology. 2016 Apr 1;27(13):135101.

19. Penetration of Gold nanoparticles through Human Skin: Unraveling Its Mechanisms at the Molecular Scale. J Phys Chem B.2016 Jul;120(29):7133-7142.

21. Layer-by-layer design and optimization of xerogel-based amperometric first generation biosensors for uric acid. J Electroanal Chem.2016 Aug;775:135-145.

23. Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. Adv Mater. 2016 Sep;28(34):7501-7.

 

2016 Jun

1. Cell-specific optoporation with near-infrared ultrafast laser and functionalized gold nanoparticles. Nanoscale. 2015 Nov; 7 (42): 17836−17847.

3. Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip. Biosens Bioelectron. 2016 Mar 15;77:491-8.

5. End Joining-Mediated Gene Expression in Mammalian Cells Using PCR-Amplified DNA Constructs that Contain Terminator in Front of Promoter. Mol Biotechnol. 2015 Dec;57(11-12):1018-29.

7. Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances. Curr Pharm Des. 2016;22(11):1506-20.

Supplement9. Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis. J Hepatol. 2016 Mar;64(3):691-8.

 

14. The influence of zinc chloride and zinc oxide nanoparticles on air-time survival in freshwater mussels. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Jun-Jul;172-173:36-44.

17. Magnetically softened iron oxide (MSIO) nanofluid and its application to thermally-induced heat shock proteins for ocular neuroprotection. Biomaterials. 2016 Sep;101:165-75.

19. Iron nanoparticle-induced activation of plasma membrane H(+)-ATPase promotes stomatal opening in Arabidopsis thaliana. Environ Sci Technol. 2015 Jan 20;49(2):1113-9.

21. Probing peptide and protein insertion in a biomimetic S-layer supported lipid membrane platform. Int J Mol Sci. 2015 Jan 27;16(2):2824-38.

23. Efficient Simulation for Light Scattering from Plasmonic Core-Shell Nanospheres on a Substrate for Biosensing. Plasmonics.2015 Aug;10(4):847-860

25. Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2016 Feb;57(2):279-84.

 

 

2. Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells. ACS Nano. 2015 Jul 28;9(7):6738-46.

4. High-speed Intravascular Photoacoustic Imaging at 1.7 μm with a KTP-based OPO. Biomed Opt Express. 2015 Nov 1; 6(11): 4557-4566.

6. Virtual-Experimental 2DE Approach in Chromosome-Centric Human Proteome Project. J Proteome Res. 2016 Feb 5;15(2):525-30.

8. Biocompatible ZnS:Mn quantum dots for reactive oxygen generation and detection in aqueous media. J Nanopart Res. 2015;17(12):461.

10. High-Throughput LC-MS/MS Method for Direct Quantification of Glucuronidated, Sulfated, and Free Enterolactone in Human Plasma. J Proteome Res. 2016 Mar 4;15(3):1051-8.

11. The responses of immune cells to iron oxide nanoparticles. Journal of Applied Toxicology. 2016 Apr. 36 (4): 543-53.

12. Commissioning optically stimulated luminescence in vivo dosimeters for fast neutron therapy. Med Phys. 2016 Jan;43(1):314.

15. Multiplex Serum Cytokine Immunoassay Using Nanoplasmonic Biosensor Microarrays. ACS Nano. 2015 April; 9(4): 4173-4181.

16. Cytotoxicity of TiO2 nanoparticles towards freshwater sediment microorganisms at low exposure concentrations. Environ Res. 2014 Nov;135:333-45.

18. AAV1/2-mediated BDNF gene therapy in a transgenic rat model of Huntington’s disease. Gene Ther. 2016 Mar;23(3):283-95.

20. Novel stable dendrimersome formulation for safe bioimaging applications. Nanoscale. 2015 Aug 14;7(30):12943-54.

22. Wnt11 gene therapy with adeno-associated virus 9 improves the survival of mice with myocarditis induced by coxsackievirus B3 through the suppression of the inflammatory reaction. J Mol Cell Cardiol. 2015 Jul;84:45-51.

24. Cerium Oxide Nanoparticles Reduce Microglial Activation and Neurodegenerative Events in Light Damaged Retina. PLoS One. 2015 Oct 15; 10(10): e0140387.

 

 

 

Stem Cells

 

2016 Oct

 

 

 

2015 Oct

 

 

BREAKING NEWS: Editors’ Picks
 

  • Stem cell disease model clarifies bone cancer trigger. Cell, April 9, 2015.
    revealed for the first time how p53, may instead drive bone cancer when genetic changes cause too much of it to be made in the wrong place.
  • New gene involved in blood-forming stem cells. JCI, April 13, 2015.
    A gene (Ash1l) critical to controlling the body’s ability to create blood cells and immune cells from blood-forming stem cells — known as hematopoietic stem cells — has been discovered by researchers. The discovery also opens new lines of inquiry about the gene’s potential role in cancers.
  • Plasticity of Hopx type I alveolar cells to regenerate type II cells in the lung. Nature Communications, April 13, 2015
    The lung cells can regenerate from one another as needed to repair missing tissue, suggesting that there is much more flexibility in the system than we have previously appreciated.
  • Stem cells born out of indecision. Cell Reports. December 18, 2014
    Researchers at the University of Copenhagen specifically found that inhibiting or blocking stem cells ability to make a specific decision, leads to better cell growth and could lead to defined ways to differentiate stem cells. This research is the first comprehensive analysis of a pathway important for stem and cancer cell decisions known as Erk. As a result this work could contain clues to cancer treatment as well as helping to establish a platform to make stem cell treatments for gut related disorders like the pancreas or the liver.
  • Lung regeneration mechanism discovered. Nature, November 12, 2014.
    The role of certain lung stem cells in regenerating lungs damaged by disease. Their work sheds light on the inner workings of the still-emerging concept of lung regeneration and points to potential therapeutic strategies that harness these lung stem cells.
  • Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model. Cell Reports, May 15, 2014.
    it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal’s own skin cells. The study in monkeys also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.

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