Cancer 2013 May-17

 

Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms.

Chemistry. 2013 Feb 25;19(9):3198-203.

Furrer MA, Garci A, Denoyelle-Di-Muro E, Trouillas P, Giannini F, Furrer J, Clavel CM, Dyson PJ, Süss-Fink G, Therrien B.

Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel, Switzerland.

Abstract

Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula [(p-cymene)(6)Ru(6)(SR)(6)(tpt)(2) ](6+) (R=CH(2)Ph, CH(2)C(6)H(4)-p-tBu, CH(2)CH(2)Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)(2)Ru(2)(SR)(2)Cl(2)], AgCF(3)SO(3) and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin-resistant cell line A2780cisR (IC(50) <0.25 μM). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID: 23344898

 

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