Cancer 2013 May-21

 

Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA complex.

J Radioanal Nucl Chem.2013 Jan;295(1):63-66.

Daniel Crístian Ferreira Soares, André Luís Branco de Barros, Raquel Gouvêa dos Santos, Edésia Martins Barros de Sousa, Gilson Andrade Ramaldes

Abstract:

In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by 159Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer.

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