Cancer 2013(8)-16

 

SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.

Biochem Soc Trans. 2012 Aug;40(4):826-30.

Hong EA, Gautrey HL, Elliott DJ, Tyson-Capper AJ.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

 

Abstract

SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.

PMID: 22817742

Multiselect Ultimate Query Plugin by InoPlugs Web Design Vienna | Webdesign Wien and Juwelier SchönmannMultiselect Ultimate Query Plugin by InoPlugs Web Design Vienna | Webdesign Wien and Juwelier Schönmann