J Cancer. 2013 Jul 19;4(6):514-8. doi: 10.7150/jca.6949.

Clinical Outcome of Small Renal Cell Carcinoma after Delayed Surgery versus Immediate Surgery.

Sugimoto K, Shimizu N, Nose K, Tahara H, Imanishi M, Nishioka T, Esa A, Kajikawa H, Uemura H.

1. Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan; ; 2. Department of Urology, Sakai Hospital Kinki University Faculty of Medicine, Sakai, Osaka, Japan;



Background: This study was undertaken to investigate the growth rate and clinical outcome of patients with a small renal mass (SRM) after delayed surgery versus immediate surgery.

Methods: We reviewed the clinical records of 328 patients with SRM ≦ 4cm at diagnosis, who underwent delayed or immediate surgical intervention from January 2000 to December 2011. Radiographic evaluation using CT scan and MRI were performed at least every 6 months and the tumor size was determined at least twice in the delayed surgery group.

Results: A total of 292 RCC patients with pT1aN0M0 were identified; among them, 32 patients had been managed with delayed surgery intervention. No statistically significant difference was observed in overall survival rate (OSR) and cancer recurrence-free rate (CRFR). But cancer-specific survival rate (CSSR) was significantly lower in the delayed surgery group (p=0.0002).

Conclusions: The overall survival rate of delayed surgery was not inferior compared with that after immediate surgery. Delayed surgery intervention for SRMs is a treatment option in the current study.

KEYWORDS: delayed surgery, immediate surgery, natural history., renal cell carcinoma, small renal mass

PMID: 23901351

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