Diabetol Metab Syndr. 2013 May 27;5(1):26.

Correlations of non-exercise activity thermogenesis to metabolic parameters in Japanese patients with type 2 diabetes.

Hamasaki H, Yanai H, Mishima S, Mineyama T, Yamamoto-Honda R, Kakei M, Ezaki O, Noda M.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan. dyanai@hospk.ncgm.go.jp.

 

Abstract:

BACKGROUND: Non-exercise activity thermogenesis (NEAT) is the energy expenditure due to physical activities besides active sports-like exercise and resistance training in daily life.

METHODS: We studied 45 subjects (22 women and 23 men) with type 2 diabetes who did not take any hypoglycemic, anti-hypertensive, or cholesterol-lowering agents and asked them about physical activity concerned with NEAT using an original questionnaire modified from a compendium of physical activities. We studied the association of the NEAT score to body weight, waist circumference, blood pressure, glucose and lipid metabolism, and arterial stiffness.

RESULTS: The NEAT score was negatively correlated with serum insulin levels (r = -0.42, P < 0.05) in all subjects. The NEAT score was also negatively correlated with waist circumference (r = -0.509, P < 0.05) and positively correlated with high-density lipoprotein-cholesterol levels (r = 0.494, P < 0.05) in women, and negatively associated with serum insulin levels (r = -0.732, p < 0.005), systolic (r = -0.482, P < 0.05) and diastolic blood pressure (r = -0.538, P < 0.05) in patients with abdominal obesity. Furthermore, the NEAT score was negatively associated with pulse wave velocity (r = -0.719, P < 0.005) in smokers.

CONCLUSION: The study demonstrated that NEAT is associated with amelioration in insulin sensitivity, waist circumference, high-density lipoprotein-cholesterol, blood pressure and the marker for atherosclerosis in patients with type 2 diabetes.

PMID: 23711224

 

Supplementary:

Non exercise activity thermogenesis (NEAT) includes various daily physical activities such as going to work, attending school, going up stairs, washing dishes, cleaning floors, singing and dancing. Surprisingly, NEAT is the most variable component of daily energy expenditure, and it varies up to 2000 kcal per day between different individuals.

The promotion of physical activity including NEAT is crucial in the management of obesity and type 2 diabetes. We, Hidetaka Hamasaki, M.D., Hidekatsu Yanai, M.D., Ph.D. and Osamu Ezaki M.D., Ph.D. developed an original questionnaire for evaluation of NEAT by modifying a compendium of physical activities to reflect more precisely Japanese daily life style [1]. Briefly, our developed questionnaire consists of 11 question items about locomotive activities such as walking and going up stairs and 25 question items about non-locomotive activities such as washing dishes and cleaning floors.

In our study, NEAT was associated with amelioration in insulin sensitivity in all patients with type 2 diabetes, and reduction of waist circumference and an increase in HDL in female patients (Figure 1). NEAT was also correlated with reduction in blood pressure in patients with abdominal obesity, and a decrease in pulse wave velocity as the marker for atherosclerosis in current smokers (Figure 1).

Hidekatsu Yanai-1To our knowledge, our study is the first to demonstrate a beneficial association of NEAT with metabolic and atherosclerotic parameters in patients with type 2 diabetes.

References:

  1. Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS: Compendiumu of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 2011;2011:1575–1581.

Hidekatsu Yanai-group

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan

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