Diabetes 2013 May (2)-14

Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.

Pediatr Diabetes. 2012 Dec;13(8):607-10

Hoffman RP, Dye AS, Bauer JA.

Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA. Roff.Hoffman@nationwidechildrens.org

Abstract

OBJECTIVE: To determine whether acute ascorbic acid infusions alter the effect of hyperglycemia on endothelial function in adolescents with type 1 diabetes.

RESEARCH DESIGN AND METHODS: The forearm blood flow (FBF) reactive hyperemic response to 5 min of upper arm occlusion was studied in eight adolescents with type 1 diabetes during euglycemic and hyperglycemic insulin clamp (40 mU/m2/min) with and without ascorbic acid infusion (3 mg/min).

RESULTS: The ratio of post- to preocclusion FBF decreased during hyperglycemia without ascorbic acid (p = 0.013), but did not change during hyperglycemia with ascorbic acid. The changes during hyperglycemia were different between the two studies (p = 0.038). Similar results were found when the percent change in forearm vascular resistance following occlusion was assessed.

CONCLUSIONS: These results indicate that antioxidant treatment with ascorbic acid blocks acute hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes. © 2012 John Wiley & Sons A/S.

PMID: 22925199

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