Diabetes 2013 May (2)-5

Verification of skin autofluorescence values by mass spectrometry in adolescents with type 1 diabetes: brief report.

Diabetes Technol Ther. 2013 Mar;15(3):269-72.

Mácsai E, Takáts Z, Derzbach L, Körner A, Vásárhelyi B.

Csolnoky Hospital, Veszprém, Hungary. macsaim1@t-online.hu

Abstract

BACKGROUND: Accumulation of advanced glycation end products (AGEs) in tissues is a major risk factor for diabetes-associated complications. Skin autofluorescence (SAF) values measured by a specific noninvasive approach (AGE Reader; DiagnOptics Technologies B.V., Gröningen, The Netherlands) reflect the overall AGE exposure in skin.

SUBJECTS AND METHODS: In 16 adolescents with type 1 diabetes (age range, 11-18 years) we tested the association between SAF measured with an AGE Reader and the presence of glucuronic acid, 3-indoxyl sulfate, 3-hydroxybutyrate, phenol sulfate, and pentosidine in skin tissue determined with desorption electrospray ionization mass spectrometry (DESI-MS). These compounds are implicated in long-term diabetes complications.

RESULTS: SAF values significantly correlated with levels of compounds measured by DESI-MS (r>0.9 and P<0.001 for each).

CONCLUSIONS: The strong correlation between adolescents’ SAF values measured with the AGE Reader and some glycation products measured with DESI-MS indicates that SAF values may be used as surrogate markers of skin exposure to glycemic end products in type 1 diabetes.

PMID: 2334333

 

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AGE: advanced glycation end-product;   GFR: glomerular filtration rate; HD:hemodialysis; PD: peritoneal dialysis; TX: kidney transplantation; RAGE: receptor of AGE; SAF: skin autofluorescence; PWV: pulse wave velocity; ET-1: endothelin-1; ICAM: intercellular adhesion molecule;  VCAM: vascular cell adhesion molecule; TNF-alfa: tumor necrosis factor alfa; IL-1: interleukin-1; IL-6: interleukin-6; ROS: reactive oxygen species; IHD: ischemic heart disease; PAD: peripheral arterial disease

 

 

 

 

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