Dis Markers. 2015;2015:128653. doi: 10.1155/2015/128653.

α-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

Aitken JP1, Ortiz C2, Morales-Bozo I2, Rojas-Alcayaga G3, Baeza M4, Beltran C5, Escobar A1.
  • 1Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.
  • 2Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.
  • 3Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile ; Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.
  • 4Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.
  • 5Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile.

 

Abstract

BACKGROUND: Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.

METHODS: 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between α-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.

RESULTS: We found a positive correlation between α-2-macroglobulin and HbA1c (r = 0.778 and P < 0.0001). Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.

CONCLUSIONS: Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

PMID: 25821337

 

 

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