Inflammation. 2016 Aug;39(4):1469-74.

The Effect of Pressure-Controlled Ventilation and Volume-Controlled Ventilation in Prone Position on Pulmonary Mechanics and Inflammatory Markers.

Şenay H1, Sıvacı R2,3, Kokulu S1, Koca B4, Bakı ED1, Ela Y1.
  • 1Medical Faculty Department of Anesthesia and Reanimation, Afyon Kocatepe University, Afyonkarahisar, Turkey.
  • 2Medical Faculty Department of Anesthesia and Reanimation, Afyon Kocatepe University, Afyonkarahisar, Turkey. remziyesivaci@gmail.com.
  • 3Tıp Fakültesi, Anesteziyoloji ve Reanimasyon AD, Kocatepe Üniversitesi, İzmir Yolu 8. Km, Afyonkarahisar, Turkey. remziyesivaci@gmail.com.
  • 4Medical Faculty Department of Medical Biochemistry, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Abstract

The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received volume-controlled ventilation, while group 2 received pressure-controlled ventilation. The demographic data, pulmonary mechanics, the inflammatory marker levels just after the induction of anesthetics, at the 6th and 12th hours, and gas analysis from arterial blood samples taken at the beginning and the 30th minute were recorded. The inflammatory marker levels increased in both groups, without any significant difference among groups. Peak inspiratory pressure level was higher in the volume-controlled ventilation group. This study revealed that there is no difference regarding inflammatory marker levels between volume- and pressure-controlled ventilation.

KEYWORDS:

inflammation; pressure controlled ventilation; prone position; volume controlled ventilation

PMID: 27221140; DOI: 10.1007/s10753-016-0379-2

 

 

 

 

 

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