Immunobiology. 2014 Dec;219(12):958-63. doi: 10.1016/j.imbio.2014.07.018.

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus.

Yu SJ1, Liao EC2, Tsai JJ3.
  • 1Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
  • 2Center for Translational Medicine, Department of Medical Research, Taichung Veterans General Hospital; Department of BioIndustry Technology, Da Yeh University, Changhua, Taiwan; Department of Medical Technology, Jen Ten College of Medicine, Nursing and Management, Miaoli, Taiwan.
  • 3Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan; Section of immunology and rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital; Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan. Electronic address: jawji@vghtc.gov.tw.

 

Abstract

Although many patients with SLE also have allergies, the immunological events triggering the onset and progression of the clinical manifestations of SLE by allergens have yet to be clarified. A total of three autoantigens, phosphoglycerate kinase 1 (PGK-1), triosephosphate isomerase (TIM) and enolase were identified by autologous serum in B cell lysate derived from HDM allergic SLE patients after Der p 2 stimulation. Autoantigen, TRIM-21 expression were also significantly increased in B cells derived from HDM allergic SLE patients. In PBMCs derived from SLE patients, the concentration of anti-PGK-1 was significantly upregulated after Der p 2 stimulation compared to HDM allergic without SLE patients and healthy subjects. Inflammatory related cytokines and chemokines include IL-1β, IL-6, IL-8, CXCL5 could be upregulated after Der p 2 stimulation in PBMCs derived from HDM allergic SLE patients. In conclusion, our data demonstrated that long-term allergen exposure could be a contributing factor in the development of SLE. Copyright © 2014 Elsevier GmbH.

KEYWORDS: Allergy; Autoantibody; Autoantigen; HDM; SLE

PMID: 25130611

 

 

 

 

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