Biomed Res Int. 2015;2015:153437. doi: 10.1155/2015/153437.

The Association between Cerebral White Matter Lesions and Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acids ratio to Cognitive Impairment Development

Suwa M1, Yamaguchi S1, Komori T2, Kajimoto S3, Kino M1.

1:Department of Cardiology, 2:Department of Radiology, Hokusetsu General Hospital,

Takatsuki, Osaka, Japan.

3:Department of rehabilitation, Aijinkai Rehabilitation Hospital, Takatsuki, Osaka, Japan.



Cerebral white matter hyperintensity (WMH) with magnetic resonance imaging (MRI) has a potential for predicting cognitive impairment. Serum polyunsaturated fatty acid (PUFA) levels are important for evaluating the extent of atherosclerosis. We investigated whether abnormal PUFA levels affected WMH grading and cognitive function in patients without significant cognitive impairment. Atherosclerotic risk factors, the internal carotid artery (ICA) plaque and serum ratios of eicosapentaenoic to arachidonic acids (EPA/AA) and docosahexaenoic to arachidonic acids (DHA/AA) were assessed in 286 patients. The relationship among these risk factors, WMH and cognitive function was evaluated using WMH grading and the Mini-Mental State Examination (MMSE). The development of WMH was associated with aging, hypertension, ICA plaques, and a low serum EPA/AA ratio (<0.38, obtained as the median value), but was not related to dyslipidemia, diabetes, smoking, and a low serum DHA/AA ratio (<0.84, obtained as the median value). In addition, the MMSE score deteriorated slightly (29.7±1.0 compared to 28.4±2.1, P<0.0001) with the progression of WMH. The progression of WMH was associated with a low serum EPA/AA ratio (<0.38) and accompanied minimal deterioration in cognitive function. Sufficient omega-3 PUFA, especially EPA, intake may be effective in preventing the development of cognitive impairment.

KEYWORDs: cognitive impairment, cerebral white matter hyperintensity, EPA/AA ratio

PMID: 26583090




Cognitive impairment and atherosclerosis

Cognitive impairment is currently related with not only neurodegenerative diseases and amyloid-βbrain accumulation but also atherosclerotic and lifestyle-related diseases. Therefore, we evaluated the relationship between cognitive impairment and cardiac function, especially left ventricular diastolic dysfunction mainly resulted from aging and atherosclerosis.


Int J Cardiol 2009; 136:351-354

Correlation between cognitive impairment and left ventricular diastolic dysfunction in patients with cardiovascular diseases.

Suwa M, Ito T.


It has been reported that cognitive impairment (CI) has been developed by atherosclerotic vascular diseases, such as diabetes, but cardiac dysfunction is also related to its development. We performed one study to elucidate the relation between cognitive function and left ventricular (LV) diastolic dysfunction in patients with various cardiovascular diseases. The Mini-Mental State Examination (MMSE) and echocardiography with tissue Doppler analysis were performed in 81 patients with various cardiovascular diseases and preserved LV ejection fraction (EF>40%). Among these 81 patients, 13 patients exhibited CI (MMSE score<24) and the remaining 68 did not (MMSE score ≥24). Brain natriuretic peptide (BNP) levels were elevated in those with CI, compared with those without. The ratio of early diastolic mitral inflow velocity to early mitral annular myocardial velocity by tissue Doppler (E/e’ as a marker of myocardial diastolic function) was elevated in those with CI, compared with those without (CI: ±1.3 vs. no CI: 4.6±1.3, p<0.0003). The prevalence of diabetes mellitus was also higher in those with CI (CI: 46% vs. no CI: 18%, p<0.025). Multivariate logistic regression analyses suggested that BNP and the Doppler index of LV diastolic function were related to CI in patients with preserved LV EF. The occurrence of CI increased with the prevalence of diabetes in elderly patients with cardiovascular diseases and LV diastolic dysfunction. Among these elderly patients, the development of CI may be related to the deterioration of LV diastolic function, possibly influenced by cardiovascular risk factors.



Michihiro Suwa, M.D., Ph.D.

Dept of Cardiology and Chief of Lab Medicine, Hokusetsu General Hospital,



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