Adv Mater. 2016 Sep;28(34):7501-7. doi: 10.1002/adma.201601976.

Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting.

Li H1, Zhang K2, Pi F1, Guo S1, Shlyakhtenko L3, Chiu W2, Shu D1, Guo P4.
  • 1College of Pharmacy/Division of Pharmaceutics and Pharmaceutical Chemistry, College of Medicine/Department of Physiology and Cell Biology/Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
  • 2Verna and Marrs McLean Department of Biochemistry and Molecular Biology, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX, 77030, USA.
  • 3Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • 4College of Pharmacy/Division of Pharmaceutics and Pharmaceutical Chemistry, College of Medicine/Department of Physiology and Cell Biology/Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA. guo.1091@osu.edu.

Abstract

RNA tetrahedral nanoparticles with two different sizes are successfully assembled by a one-pot bottom-up approach with high efficiency and thermal stability. The reported design principles can be extended to construct higher-order polyhedral RNA architectures for various applications such as targeted cancer imaging and therapy.

KEYWORDS: Phi29 packaging RNA; RNA nanoparticles; RNA nanotechnology; tetrahedrons; three-way junctions

PMID: 27322097

 

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