Obesity 1-2

beta-Cell Mass and Turnover in Humans Effects of obesity and aging

Y. Saisho, A. E. Butler, E. Manesso, D. Elashoff, R. A. Rizza and P. C. Butler

Diabetes Care.2013 Jan;36(1):111-117.

Abstract: OBJECTIVE-We sought to establish beta-cell mass, beta-cell apoptosis, and beta-cell replication in humans in response to obesity and advanced age. RESEARCH DESIGN ANDMETHODS-We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on beta-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. RESULTS-beta-Cell mass is increased by similar to 50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but beta-cell mass is remarkably preserved. There is minimal beta-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age. CONCLUSIONS-beta-Cell mass in human obesity increases by similar to 50% by an increase in beta-cell number, the source of which is unknown. beta-Cell mass is well preserved in humans with advanced aging. Diabetes Care 36: 111-117, 2013

*Times cited: 2

Keywords: type-2 diabetes-mellitus, insulin-resistance, apoptosis, replication, expansion, secretion

Link: http://www.ncbi.nlm.nih.gov/pubmed/22875233

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