Osteoporosis 2013 July-11

 

Utility of serum tartrate-resistant acid phosphatase isoform 5b, bone alkaline phosphatase and osteocalcin in osteoporotic fractures in Chinese patients.

Clin Lab. 2012;58(7-8):845-50.

Cao Y, Liu X, Xu H.

Department of Orthopaedics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China; Department of Pharmacology, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China. E-mail: haibo.xu@cdutcm.edu.cn

 

Abstract

BACKGROUND: The goal was to find out the clinical significances of tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), a biomarker of bone resorption, bone alkaline phosphatase (BAP) and osteocalcin, two markers of bone formation, in evaluating the osteoporotic fracture risk in Chinese patients.

METHODS:     Thirty six Chinese osteoporotic fracture patients and 32 Chinese healthy subjects were included in the study. Bone mineral density (BMD) of lumbar spine and total body in all subjects were determined by dual-energy X-ray absorptiometry. Fasting blood samples were collected from all subjects and the serum concentrations of TRACP 5b, BAP and osteocalcin were analyzed with enzyme-linked immunosorbent assay or immunoradiometric assay.

RESULTS:     With lower BMD, the osteoporotic fracture patients had elevated level of TRACP 5b and BAP, compared with the healthy control. No difference in serum osteocalcin level was observed between the fracture patients and the control.

CONCLUSIONS: Elevated serum TRACP 5b and BAP, combined with or without increased osteocalcin, are valuable tools for the assessment of osteoporotic fracture risk in Chinese patients.

PMID: 22997989

 

Press release:

Increased osteocalcin is not a marker of osteoporotic fracture risk in Chinese patients.

Research published in Clinical Laboratory suggests that elevated serum level of osteocalcin may be not associated with increased osteoporotic fracture risk in Chinese patients.

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, with a subsequent increase in bone fragility. One of the severest consequences of osteoporosis is osteoporotic fracture, which is now becoming a major and global public health burden.

Mounting data unveil that the increases in TRACP 5b, BAP and osteocalcin are correlated to osteoporosis, whereas bone turnover markers greatly vary with age, gender and race, and are influenced by genetic factor, geographic setting and lifestyle. As the majority of previous studies were conducted on Caucasian or Japanese populations, the relations between bone turnover markers and osteoporosis, and especially osteoporotic fracture, in Chinese ethnicity are elusive.

The researcher from Chengdu University of Traditional Chinese Medicine, collaborating with a group at the Second Affiliated Hospital of Guangzhou Medical University, investigated the relations between TRACP 5b, BAP and osteocalcin and osteoporotic fractures in Chinese patients. The intriguing results of this study indicate that osteoporotic fracture patients with lower BMD had elevated serum level of TRACP 5b and BAP, compared with the healthy participants, while no difference in osteocalcin level was observed between the fracture patients and the control.

Dr. Haibo Xu who led this research explained, “Our results suggest that osteocalcin as a marker of bone formation is of limited clinical value for osteoporotic fracture risk in Chinese patients. As osteocalcin is also a marker of bone resorption reported recently, in addition to bone formation, we speculate that osteocalcin reflects the imbalance of bone formation and bone resorption, and its expression is regulated by an unknown complex mechanism, which merits intensive investigation.” This study provides a novel insight into the utility of some bone turnover markers for the assessment of osteoporotic fracture risk, the prognosis of osteoporotic fracture and monitoring the efficacy of antiosteoporotic therapy in Chinese patients.

 

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