Obesity. 2013 May;21(5):921-7. doi: 10.1002/oby.20211.

Efficacy and tolerability of a novel herbal formulation for weight management.

Stern JS, Peerson J, Mishra AT, Sadasiva Rao MV, Rajeswari KP.

Department of Nutrition, University of California Davis, Davis, California, USA. jsstern@ucdavis.edu



OBJECTIVE: To evaluate the efficacy of an herbal blend.

DESIGN AND METHODS: A randomized, double-blind, clinical trial in 60 subjects with body mass index (BMI) between 30 and 40 kg/m(2) . Participants were randomized into two groups receiving either 400 mg herbal capsules or 400 mg placebo capsules twice daily. The herbal blend comprises of extracts from Sphaeranthus indicus and Garcinia mangostana. Participants received a standard diet (2,000 kcal per day) and walked 30 min 5 days per week.

RESULTS: After 8 weeks, significant net reductions in body weight (3.74 kg; P < 0.0001), BMI (1.61 kg/m(2) ; P < 0.0001), and waist circumference (5.44 cm; P < 0.05) were observed in the herbal group compared with placebo. Additionally, a significant increase in serum adiponectin concentration was found in the herbal group versus placebo (P = 0.001). Adverse events were mild and were equally distributed between the two groups. In vitro studies in the 3T3-L1 adipocyte cell line showed that the herbal extract markedly downregulated the expression of peroxisome proliferator-activated receptor gamma, adipocyte-differentiation related protein, and cluster of differentiation 36 but increased adiponectin expression. The herbal extract also reduced the expression and the recruitment of perilipin onto the membrane of lipid droplets.

CONCLUSION: Supplementation with the herbal blend resulted in a greater degree of weight loss than placebo over 8 weeks.

Copyright © 2012 The Obesity Society.

PMID: 23784895


Meratrim Obesity Research Summary

Weight gain is the result of excess production of adipose tissue (fat tissue) as well as the deposition of increased amount of lipid droplets per cell. Weight gain also results from a decrease in lipolysis (fat break down). Lipolysis happens when we expend more energy/burn more calories than we consume. Understanding of adipocyte formation and the cellular and molecular basis of fat tissue growth and break down can lead to helpful strategies for weight management. Combined with a healthy diet and moderate exercise, ingredients that inhibit adipogenesis and increase lipolysis may help in weight loss efforts.

Meratrim® is a proprietary blend of two plant extracts, Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind. Each plant contributes an essential part to Meratrim’s ability to affect multiple pathways involved in fat cell formation and breakdown for ultimate weight management benefts. S. indicus and G. mangostana have been traditionally used in Southeast Asian culture.1,2 It is made by combining extracts of S. indicus flower heads, standardized to 5% 7-hydroxyfrullanolide, with extracts of the fruit rind of G. mangostana, standardized to 10% a-mangostin in a 3:1 ratio.

Results from Meratrim clinical trials as well as safety research have been presented at prestigious scientific meetings such as Experimental Biology, Obesity Society, American Society of Bariatric Physicians and American College of Nutrition. The Meratrim 60-subject study was published in the journal, Obesity.[1] The clinical results demonstrate Meratrim’s role in regulating normal fat metabolism and managing healthy weight.

The randomized, double-blind, placebo-controlled research published in Obesity demonstrated the significant effect Meratrim has on weight loss and the reduction of hip and waist circumference when compared to placebo in 60 subjects.


Summary of Meratrim® Clinical Research – 60 Subject Study

Study Design

  • Fifty-six subjects who completed the trial (average weight of 180.34 lbs and BMI of 33.90 kg/m2) took 400 mg of Meratrim (n=29) or placebo (n=27) twice daily (30 minutes before breakfast & dinner) for 8 weeks.
  • Four subjects were lost to follow up. Their data was not analyzed as per the study protocol.
  • All subjects followed a standard 2,000 kcal/day diet (61% carbohydrates; 14% protein; 25% fat) and walked for 30 minutes five days a week.
  • All subjects completed a questionnaire regarding medical history, compliance with exercise regimen and diet at baseline and during follow up evaluations at 2, 4, and 8 weeks.

Improvement in Anthropometric Parameters                

  • Meratrim significantly reduced body weight by 11.2 lbs after eight weeks, 3.8-times more than placebo (p<0.0001), which reduced body weight by 2.95 lbs.
  • Significant reduction in body weight of 4.1 lbs was seen as early as two weeks, 3.3-fold better than placebo (p<0.0001), which reduced body weight by 1.2 lbs at two weeks.
  • A significant reduction of 1.66 inches in waist size was seen after two weeks (p<0.0163). Placebo reduced waist size by 0.33 inches.
  • At eight weeks, Meratrim significantly reduced waist size better than placebo with a reduction of 4.66 inches in the waist (p<0.0004). Placebo reduced waist size by 2.52 inches.

Modulation of Biochemical Markers

  • Adiponectin levels increased 25-fold as compared to placebo (p<0.0011). Meratrim increased adiponectin levels by 0.93 µg/ml. Placebo increased adiponectin levels by 0.036 µg/ml.
  • Meratrim also significantly modulated cholesterol and triglyceride levels.

Safety Conclusion

  • No major adverse events occurred during the study.
  • The minor adverse events seen were evenly dispersed between the placebo and the Meratrim groups.

The published clinical research demonstrates that Meratrim is an effective and well-tolerated supplement that supports healthy body weight loss. Meratrim recommended use is 400 mg 30 minutes before breakfast and dinner. Judith Stern, Sc.D, Distinguished Professor in the Departments of Nutrition and Internal Medicine/Division of Clinical Nutrition and Metabolism at the University of California, Davis, oversaw the final analysis and communication of the trial. Results from the 60-subject study can be found in the July 2013 issue of Obesity.


[1]. Stern JS, Peerson J, Mishra AT, et al. Efficacy and tolerability of a novel herbal formulation for weight management. Obesity. 2013;21:921-927.

Multiselect Ultimate Query Plugin by InoPlugs Web Design Vienna | Webdesign Wien and Juwelier SchönmannMultiselect Ultimate Query Plugin by InoPlugs Web Design Vienna | Webdesign Wien and Juwelier Schönmann