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3. The Bisphenol A analogue Bisphenol S binds to K-Ras4B – implications for ‘BPA-free’ plastics. FEBS Letters. 2016 Feb;590(3):369–375.
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1. The Efficacy of Continued Sorafenib Treatment after Radiologic Confirmation of Progressive Disease in Patients with Advanced Hepatocellular Carcinoma. PLoS One. 2016 Jan 8;11(1):e0146456.
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BREAKING NEWS: Editors’ Picks
- Acquisition of Portal Venous Circulating Tumor Cells From Patients With Pancreaticobiliary Cancers by Endoscopic Ultrasound. Gastroenterology, November 23, 2015
New test may improve diagnosis, treatment of pancreactic cancers: Collecting blood samples from the portal vein can provide much more information about pancreatic cancer than taking blood from vein in the arm. Researchers found circulating tumors cells in 100 percent of 18 patients with suspected tumors in the pancreas and bile ducts.
- Arthritis drug could be used to treat blood cancer sufferers. PLOS ONE, July 5, 2015
Methotrexate (MTX) can work in the same way as the drug Ruxolitinib, but is one thousandth of the cost.
- Immune Cells and Virus Team Up to Fight Cancer. Science Translational Medicine, March 5, 2014.
The findings demonstrate that localized therapy with oncolytic NDV induces inflammatory immune infiltrates in distant tumors, making them susceptible to systemic therapy with immunomodulatory antibodies, which provides a strong rationale for investigation of such combination therapies in the clinic.
- New leukemia immune cell therapy shows promise. Science Translational Medicine, February 19, 2014:
In the latest and largest clinical study yet conducted in patients with advanced leukemia, 14 of the 16 patients – that is 88% – treated with genetically modified versions of their own immune cells, achieved complete remission, at least in the short term.
- The PRKC1 and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma. Cancer Cell, February 10, 2014.
PKC1 and SOX2 are genetically, biochemically, and functionally linked in LSCC, and together they drive tumorigenesis by establishing a cell-autonomous Hh signaling axis.
- UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma. Cancer Cell, January 30, 2014
Overexpression of UHRF1, a critical DNA methylation regulator, in zebrafish causes DNA hypomethylation, p53-mediated senescence, and hepatocellular carcinoma (HCC) when senescence is bypassed. UHRF1 overexpression is a mechanism underlying DNA hypomethylation in cancer cells and that senescence is a primary means of restricting tumorigenesis due to epigenetic disruption.
- Molecular Engines Star in New Model of DNA Repair. Nature, January 16, 2014.
UvrD is a transcription elongation factor that binds RNA polymerase and promotes its backwards movement when it becomes stalled at a lesion. NusA, another elongation factor, assists in promoting backtracking and helps UvrD to target other nucleotide excision repair factors to the exposed lesion.The result: fewer mutations and consequently less cancer and other kinds of disease.