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BREAKING NEWS: Editors’ Picks
- A new study suggests Alzheimer’s disease may come from the brain infections. Science Translational Medicine, 2016 May.
The new study could change the way we think about the disease, and develop new drugs for treatment.
- New Alzheimer’s disease causing proline substitutions. The EMBO Journal, Nov 3, 2015
The failure to develop efficient Alzheimer’s therapy might come from the pooling, in clinical experiments, of patients who suffer from distinct disorders that eventually lead to Alzheimer’s symptoms. Therefore it is essential to carefully characterize and classify the mechanisms that underlie Alzheimer’s disease, in order to allow for the development of novel therapies.
- Modulating brain’s stress circuitry might prevent alzheimer’s disease. Alzheimer’s & Dementia, Nov 16, 2015.
long-term treatment using a small molecule drug that reduces activity of the brain’s stress circuitry significantly reduces Alzheimer’s disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.
- Alzheimer protein’s structure may explain its toxicity. Nature Structural & Molecular Biology, 2015 May.
Knowing the physical structure of the 42 amino acid-long form of amyloid beta in the fibers is key to understanding how it folds up improperly and aggregates into toxic plaques.
- New link between diabetes and Alzheimer. Journal of Clinical Investigation, 2015 May
A unique connection between diabetes and Alzheimer’s disease has been uncovered, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar.
- Major pathway (SARM1) identified in nerve cell death offers hope for therapies. Science, 2015 April
New research highlights how nerves start to die, a discovery that unveils novel targets for developing drugs to slow or halt peripheral neuropathies and devastating neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
- ‘Tangles’ trigger early-stage Alzheimer’s abnormalities in neocortical networks. Neuron, 2015 March.
The study’s dramatic results are due, in part, to the scientists’ decision to focus on a seldom-studied brain cell pathology known as “tangles”.
- Even mild traumatic brain injury may cause brain damage. Neurology, 2014 July.
Those with injuries had brain damage in brain white matter consisting of disruption to nerve axons. This finding is especially important, as 90 percent of all traumatic brain injuries are mild to moderate.
- Autophagy mediates the formation of amyloid beta plaques. Cell Reports, 2013 October.
The study sheds light on the metabolism of amyloid beta, and its role in neurodegeneration and memory loss. It might be a potential drug target for the treatment of the disease.
- XIAP Regulates Caspase Activity in Degenerating Axons. Cell Reports, 2013 August.
Excessive nerve cell pruning leads to disease. Scientists have made important discoveries about a cellular process that occurs during normal brain development and may play an important role in neurodegenerative diseases. The study’s findings point to new pathways and targets for novel therapies for Alzheimer’s.
- Prion-like proteins drive several diseases of aging. Nature, 2013 September
A new emerging concept that many of the brain diseases associated with aging, such as Alzheimer’s and Parkinson’s, are caused by specific proteins that misfold and aggregate into harmful seeds. These seeds behave very much like the pathogenic agents known as prions, which cause mad cow disease.