Stem Cells

 

2016 Oct

 

 

 

2015 Oct

 

 

BREAKING NEWS: Editors’ Picks
 

  • Stem cell disease model clarifies bone cancer trigger. Cell, April 9, 2015.
    revealed for the first time how p53, may instead drive bone cancer when genetic changes cause too much of it to be made in the wrong place.
  • New gene involved in blood-forming stem cells. JCI, April 13, 2015.
    A gene (Ash1l) critical to controlling the body’s ability to create blood cells and immune cells from blood-forming stem cells — known as hematopoietic stem cells — has been discovered by researchers. The discovery also opens new lines of inquiry about the gene’s potential role in cancers.
  • Plasticity of Hopx type I alveolar cells to regenerate type II cells in the lung. Nature Communications, April 13, 2015
    The lung cells can regenerate from one another as needed to repair missing tissue, suggesting that there is much more flexibility in the system than we have previously appreciated.
  • Stem cells born out of indecision. Cell Reports. December 18, 2014
    Researchers at the University of Copenhagen specifically found that inhibiting or blocking stem cells ability to make a specific decision, leads to better cell growth and could lead to defined ways to differentiate stem cells. This research is the first comprehensive analysis of a pathway important for stem and cancer cell decisions known as Erk. As a result this work could contain clues to cancer treatment as well as helping to establish a platform to make stem cell treatments for gut related disorders like the pancreas or the liver.
  • Lung regeneration mechanism discovered. Nature, November 12, 2014.
    The role of certain lung stem cells in regenerating lungs damaged by disease. Their work sheds light on the inner workings of the still-emerging concept of lung regeneration and points to potential therapeutic strategies that harness these lung stem cells.
  • Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model. Cell Reports, May 15, 2014.
    it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal’s own skin cells. The study in monkeys also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.

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