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Product Description
Calreticulin Rabbit pAb |ELK Biotechnology Antibodies | is available at Gentaur for Next Week Delivery
Product Background: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .
Source: Rabbit
Application: WB
Species Reactivity: Human,Mouse,Rat
Recommended Dilution: WB 1:500-1,000
Immunogenecity: Recombinant Protein
Speceficity: Human
Purification: N/A
Isotype: IgG
Observed Brand: 55 kDa
Cellular Localization: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted
Alternative Names: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA
Gene ID (Human): 811
Human Swiss-Protein No. : P27797
