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Product Description
Crk II (phospho Tyr221) Polyclonal Antibody |ELK Biotechnology Antibodies | is available at Gentaur for Next Week Delivery
Product Background: CRK proto-oncogene, adaptor protein(CRK) Homo sapiens This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],
Source: Rabbit
Application: WB,IF,ELISA
Species Reactivity: Human,Mouse,Rat,Monkey
Recommended Dilution: N/A
Immunogenecity: The antiserum was produced against synthesized peptide derived from human CrkII around the phosphorylation site of Tyr221. AA range:187-236
Speceficity: N/A
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype: N/A
Observed Brand: 40 kDa
Cellular Localization: N/A
Alternative Names: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
