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Product Description
COX1/Cyclooxygenase 1 Rabbit pAb |ELK Biotechnology Antibodies | is available at Gentaur for Next Week Delivery
Product Background: Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be describedGalectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Galectin 3 is normally distributed in epithelia of many organs, in various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.
Source: Rabbit
Application: WB, IHC
Species Reactivity: Human
Recommended Dilution: WB 1:1,000 IHC 1:100
Immunogenecity: Synthetic Peptide
Speceficity: Human
Purification: N/A
Isotype: IgG
Observed Brand: 70 kDa
Cellular Localization: Endoplasmic reticulum, Membrane, Microsome
Alternative Names: N/A
Gene ID (Human): 5742
Human Swiss-Protein No. : P23219
